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dc.contributor.authorLong, J.
dc.contributor.authorEtxeberria, A. E.
dc.contributor.authorKornelsen, C.
dc.contributor.authorRay, S.
dc.contributor.authorBunt, C. R.
dc.contributor.authorSeyfoddin, A.
dc.date.accessioned2019-09-20T01:30:05Z
dc.date.available2019-09-20T01:30:05Z
dc.date.issued2019-06-05
dc.identifier.issn2576-6422
dc.identifier.urihttps://hdl.handle.net/10652/4698
dc.description.abstractThis study reports on the fabrication of a controlled release system for the delivery of levonorgestrel (LNG) for long-term contraception. LNG was encapsulated in chemically cross-linked chitosan (CS) microspheres, and microspheres presented a spherical geometry with a good particle size distribution (polydispersity index (PDI) < 0.1). The LNG-CS microspheres were classified based on their particle size range, <63, 63–125, and 125–300 μm, where the 125–300 μm particles were selected to be incorporated into a physically cross-linked and annealed PVA hydrogel matrix to prolong the drug release. PVA concentrations and the annealing treatment influenced the swelling behavior of PVA hydrogels. Fourier transform infrared (FTIR) spectroscopy indicated that CS was successfully cross-linked through the formation of a Schiff base; the PVA hydrogel was formed through hydrogen bonding without reacting with LNG, which was only physically entrapped, thus maintaining its stability. Differential scanning calorimetry (DSC) showed that freeze–thaw and annealing processes increased the degree of crystallinity in the PVA hydrogel. In vitro drug release assessments for all formulations showed zero order without any burst release. Over a period of 100 days, 34, 27, and 21% of LNG was released from the CS-LNG microspheres in the size ranges < 63, 63–125, and 125–300 μm, respectively, while only 14, 11, and 9% of LNG was released when the CS-LNG microspheres were incorporated into 10, 15, and 20% PVA hydrogels, respectively. The drug release kinetics exhibited both diffusion- and swelling-controlled mechanisms following the Korsmeyer–Peppas model. This work presents a promising delivery system for long-term contraception with controlled zero-order release behavior [ROMS = 64350] Nand, A. V. = Unitec authoren_NZ
dc.language.isoenen_NZ
dc.subjectlevonorgestrelen_NZ
dc.subjectcontrolled releaseen_NZ
dc.subjectlong-termen_NZ
dc.subjectmicrosphereen_NZ
dc.subjecthydrogelen_NZ
dc.subjectchitosanen_NZ
dc.subjectpoly (vinyl alcohol)en_NZ
dc.titleDevelopment of a long-term drug delivery system with levonorgestrel loaded chitosan microspheres embedded in poly (vinyl alcohol) hydrogel [embargo to JUNE 2020]en_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderCopyright © 2019 American Chemical Societyen_NZ
dc.identifier.doihttps://doi.org/10.1021/acsabm.9b00190en_NZ
dc.subject.marsden1101 Medical Biochemistry and Metabolomicsen_NZ
dc.identifier.bibliographicCitationLong, J., Etxeberria, A. E., Kornelsen, C., Nand, A. V., Ray, S., Bunt, C. R., & Seyfoddin, A. (2019). Development of a long-term drug delivery system with levonorgestrel-loaded chitosan microshperes embedded in poly(vinyl alcohol) hydrogel. ACS Applied Bio Materials, 2, 2766-2779. doi:10.1021/acsabm.9b00190
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.peerreviewedyesen_NZ


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