• Login
    View Item 
    •   Research Bank Home
    • Study Areas
    • Community and Health Services
    • Community and Health Services Journal Articles
    • View Item
    •   Research Bank Home
    • Study Areas
    • Community and Health Services
    • Community and Health Services Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The possible protective role of magnesium on Ciprofloxacin Induced chondrotoxicity on the epiphyseal plate growth of juvenile albino rat : a histological and morphometric study

    Aziz, Joseph; Morgan, M.

    Thumbnail
    Share
    View fulltext online
    Vol1Issue1_4OA.pdf (435.5Kb)
    Date
    2015-12-24
    Citation:
    Aziz, J., & Morgan, M. (2015). The Possible Protective Role of Magnesium on Ciprofloxacin Induced Chondrotoxicity on the Epiphyseal Plate Growth of Juvenile Albino Rat: A Histological and Morphometric Study. Academia Anatomica International, 1(1), pp.13-19. doi:10.21276/aanat.2015.1.1.4
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/4081
    Abstract
    BACKGROUND: Ciprofloxacin is one of the most effective antibiotics used in the treatment of many infectious diseases in adults, but it has undesirable toxic effects on the growing cartilage. The present study was designed to detect the toxic effect of ciprofloxacin on growing cartilage in the immature albino rats and the possible protective role of magnesium in prevention of such toxicity. METHODS: Seventy rats were used in the current study. They were divided into five groups: Group I: control group, group II: ciprofloxacin treated group, group III: magnesium given before ciprofloxacin, group IV: ciprofloxacin with magnesium and group V: magnesium given after ciprofloxacin). The region of the knee joint was prepared and stained with hematoxylin and eosin stain for light microscopic examination. Morphometric studies were also done using the image analyzer. RESULTS: ciprofloxacin treated group revealed different changes in the tibial epiphyseal growth plate of juvenile rats in the form of decreased thickness, loss of chondrocytes, karryorrhexis, pyknotic nuclei, interlacunar hemorrhage, irregularity in the columns and myxomatous degeneration. Partial improvement was observed in the group treated with magnesium before ciprofloxacin and in the group treated with magnesium concurrently with ciprofloxacin, meanwhile no improvement was detected in the group treated with magnesium given after ciprofloxacin. CONCLUSION: The present study concluded that the use of ciprofloxacin in juvenile rats caused epiphyseal plate growth retardation; accordingly the use of this drug in pediatrics should be restricted to carefully selected indications. Owing to its protective role in reducing such chondrotoxic effects, the use of magnesium before (in chronic cases like cystic fibrosis of the lung) and concomitantly with ciprofloxacin is highly recommended.
    Keywords:
    cartilage, Ciprofloxacin, antibiotics, epiphyseal plate, histology, magnesium, morphometry
    ANZSRC Field of Research:
    11 Medical and Health Sciences
    Copyright Holder:
    Authors
    Copyright Notice:
    © the author(s), publisher. Academia Anatomica International is an Official Publication of “Society for Health Care & Research Development”. It is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is cited.
    Available Online at:
    http://aanat.aijournals.com/Upload/Vol1Issue1_4OA.pdf
    ORCID Author Profiles
    • https://orcid.org/0000-0003-1393-0701
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
    Metadata
    Show detailed record
    This item appears in
    • Community and Health Services Journal Articles [11]

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142
     

     

    Usage

    Downloads, last 12 months
    50
     
     

    Usage Statistics

    For this itemFor the Research Bank

    Share

    About

    About Research BankResearch at UnitecContact us

    Help for authors  

    How to add researchOpen Access GuideVersions Toolkit

    Register for updates  

    LoginRegister

    Browse Research Bank  

    EverywhereAcademic study areasAuthorDateSubjectTitleType of researchSupervisorThis CollectionAuthorDateSubjectTitleType of researchSupervisor

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142