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    Assessment of a carbon dioxide laser for the measurement of thermal nociceptive thresholds following intra-muscular administration of analgesic drugs to pain-free female cats

    Farnworth, Mark; Barrett, Lorelle; Adams, Nigel; Beausoleil, N.J.; Weidgraaf, K.; Hekman, M.; Chambers, J.P.; Thomas, D.G.; Waran, N.K.; Stafford, K.J.

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    Assessment of lasers for measurement of laser for thermal nociceptor thresholds.pdf (750.6Kb)
    Date
    2015-02-14
    Citation:
    Farnworth, M. J., Barrett, L. A., Adams, N. J., Beausoleil, N. J., Weldgraaf, K., Hekmann, M., Chambers, J. P., Thomas, D. G., Waran, N. K., & Stafford, K. J. (2015). Assessment of a carbon dioxide laser for the measurement of thermal nociceptive thresholds following intra-muscular administration of analgesic drugs to pain-free female cats. Journal of Veterinary Analgesia, 42 (6), pp.638-647. doi:10.1111/vaa.12245
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/3455
    Abstract
    OBJECTIVE: To assess the potential of a thermal carbon dioxide (C02) laser to explore antinociception in pain-free cats. STUDY DESIGN: Experimental. prospective, blinded, randomlsed study ANIMALS: Sixty healthy adult female cats with a (mean ± standard deviation) weight of 3.3 ± 0.6 kg. METHODS: Cats were systematically allocated to one of six treatments: saline 0.2 mL per cat; morphine 0.5 mg kg-1; buprenorphine 20 mcg kg-1; medetomidine 2 mcg kg-1 ; tramadol 2 mg kg-1, and ketoprofen 2 mg kg-1. Latency to respond to thermal stimulation was assessed at baseline and at intervals of 15–30, 30–45, 45–60, 60–75, 90–105 and 120–135 minutes. Thermal thresholds were assessed using time to respond behaviourally to stimulation with a 500 mW CO2 laser. Within-treatment differences in response latency were assessed usingFriedman’s test. Differences amongst treatments were assessed using independent Kruskal–Wallistests. Where significant effects were identified, pair-wise comparisons were conducted to elucidate the direction of the effect. RESULTS: Cats treated with morphine ( [symbol] 2= 12.90, df = 6, p = 0.045) and tramadol (symbol] 2= 20.28, df = 6, p = 0.002) showed significant increases in latency to respond. However, subsequent pairwise comparisons indicated that differences in latencies at specific time-points were significant (p < 0.05) only for tramadol at 60–75 and 90–105 minutes after administration (21.9 and 43.6 seconds, respectively) in comparison with baseline (11.0 seconds). No significant pairwise comparisons were found within the morphine treatment. Injections of saline, ketoprofen, medetomidine or buprenorphine showed no significant effect on latency to respond. The CO2 laser technique may have utility in the assessment of thermal nociceptive thresholds in pain-free cats after analgesic administration and may provide a simpler alternative to existing systems. Further exploration is required to examine its sensitivity and comparative utility.
    Keywords:
    domestic cats (Felis catus), female cats, cats (Felis catus), analgesia, CO2 lasers, nociception tests
    ANZSRC Field of Research:
    070701 Veterinary Anaesthesiology and Intensive Care
    Copyright Holder:
    © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia
    Copyright Notice:
    © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
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