• Login
    View Item 
    •   Research Bank Home
    • Study Areas
    • Health Sciences
    • Health Sciences Journal Articles
    • View Item
    •   Research Bank Home
    • Study Areas
    • Health Sciences
    • Health Sciences Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: results from the MAGGIC individual patient meta-analysis

    Jackson, Colette E.; Castagno, Davide; Maggioni, A.P.; Køber, Lars; Squire, I.B.; Swedberg, Karl; Andersson, Bert; Richards, A.M.; Bayes-Genis, Antoni; Tribouilloy, Christophe; Dobson, Joanna; Ariti, Cono A.; Poppe, K.K.; Earle, Nikki; Whalley, Gillian; Pocock, Stuart J.; Doughty, Robert N.; McMurray, John J.V.

    Thumbnail
    Share
    View fulltext online
    DIFFERING PROGNOSTIC VALUE.pdf (226.9Kb)
    Date
    2015-01-23
    Citation:
    Jackson, C.E., Castagno, D., Maggioni, Aldo P., Køber, L., Squire, I.B., Swedburg, K., Anderssonn, B., Richards, M.A., Bayes-Genis, Tribouilloy, C., Dobson, J., Airiti, Cono A., Poppe, K.K., Earle, N., Whalley, G., Pocock, S.J., Doughty, R.N., and McMurray, J.J.V. doi:10.1093/eurheartj/ehu490
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/3201
    Abstract
    AIMS: Low pulse pressure is a marker of adverse outcome in patients with heart failure (HF) and reduced ejection fraction (HFREF) but the prognostic value of pulse pressure in patients with HF and preserved ejection fraction (HF-PEF) is unknown. We examined the prognostic value of pulse pressure in patients with HF-PEF [ejection fraction (EF) ≥ 50%] and HF-REF. METHODS AND RESULTS: Data from 22 HF studies were examined. Preserved left ventricular ejection fraction (LVEF) was defined as LVEF ≥ 50%. All-cause mortality at 3 years was evaluated in 27 046 patients: 22 038 with HF-REF (4980 deaths) and 5008 with HFPEF (828 deaths). Pulse pressure was analysed in quintiles in a multivariable model adjusted for the previously reported Meta-Analysis Global Group in Chronic Heart Failure prognostic variables. Heart failure and reduced ejection fraction patients in the lowest pulse pressure quintile had the highest crude and adjusted mortality risk (adjusted hazard ratio 1.68, 95% confidence interval 1.53–1.84) compared with all other pulse pressure groups. For patients with HF-PEF, higher pulse pressure was associated with the highest crude mortality, a gradient that was eliminated after adjustment for other prognostic variables. CONCLUSION: Lower pulse pressure (especially ,53 mmHg) was an independent predictor of mortality in patients with HF-REF, particularly in those with an LVEF , 30% and systolic blood pressure ,140 mmHg. Overall, this relationship between pulse pressure and outcome was not consistently observed among patients with HF-PEF.
    Keywords:
    pulse pressure, heart failure, reduced ejection fraction, preserved ejection fraction, mortality, Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC), cardiomyopathy
    ANZSRC Field of Research:
    110201 Cardiology (incl. Cardiovascular Diseases)
    Copyright Holder:
    European Society of Cardiology
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
    Metadata
    Show detailed record
    This item appears in
    • Health Sciences Journal Articles [49]

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142
     

     

    Usage

    Downloads, last 12 months
    57
     
     

    Usage Statistics

    For this itemFor the Research Bank

    Share

    About

    About Research BankResearch at UnitecContact us

    Help for authors  

    How to add researchOpen Access GuideVersions Toolkit

    Register for updates  

    LoginRegister

    Browse Research Bank  

    EverywhereAcademic study areasAuthorDateSubjectTitleType of researchSupervisorThis CollectionAuthorDateSubjectTitleType of researchSupervisor

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142