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dc.contributor.authorHach, Sylvia
dc.contributor.authorTippett, Lynette J.
dc.contributor.authorAddis, Donna Rose
dc.date.accessioned2015-09-30T21:36:33Z
dc.date.available2015-09-30T21:36:33Z
dc.date.issued2014-12
dc.identifier.issn0028-3932
dc.identifier.urihttps://hdl.handle.net/10652/3052
dc.description.abstractIt is well established that individuals affected by depression experience difficulty in remembering the past and imagining the future. This impairment is evident in increased rumination on non-specific, generic events and in the generation of fewer specific events during tasks tapping past and future thinking. The present fMRI study investigated whether neural changes during the construction of autobiographical events was evident in depression, even when key aspects of performance (event specificity, vividness) were matched. We employed a multivariate technique (Spatiotemporal Partial Least Squares) to examine whether task-related whole brain patterns of activation and functional connectivity of the hippocampus differed between depressed participants and non-depressed controls. Results indicate that although the depression group retained the ability to recruit the default network during the autobiographical tasks, there was reduced activity in regions associated with episodic richness and imagery (e.g., hippocampus, precuneus, cuneus). Moreover, patterns of hippocampal connectivity in the depression group were comparable to those of the control group, but the strength of this connectivity was reduced in depression. These depression-related reductions were accompanied by increased recruitment of lateral and medial frontal regions in the depression group, as well as distinct patterns of right hippocampal connectivity with regions in the default and dorsal attention networks. The recruitment of these additional neural resources may reflect compensatory increases in post-retrieval processing, greater effort and/or greater self-related referential processing in depression that support the generation of specific autobiographical events.en_NZ
dc.language.isoenen_NZ
dc.publisherElsevieren_NZ
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0028393214003637en_NZ
dc.subjectautobiographical memoryen_NZ
dc.subjectfuture simulationen_NZ
dc.subjectdepression (psychology)en_NZ
dc.subjectPartial Least Squaresen_NZ
dc.subjecthippocampusen_NZ
dc.subjectconnectivityen_NZ
dc.subjectfMRIen_NZ
dc.titleNeural changes associated with the generation of specific past and future events in depressionen_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderElsevieren_NZ
dc.identifier.doidoi:10.1016/j.neuropsychologia.2014.10.003en_NZ
dc.subject.marsden170205 Neurocognitive Patterns and Neural Networksen_NZ
dc.identifier.bibliographicCitationHach, S., Tippett, L. J., and Addis, D. R. (2014). Neural changes associated with the generation of specific past and future events in depression. Neuropsychologia, 65, pp.41-55. NOTE: Available from link below.en_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.institutionUniversity of Aucklanden_NZ
unitec.publication.spage41en_NZ
unitec.publication.lpage55en_NZ
unitec.publication.volume65en_NZ
unitec.publication.titleNeuropsychologiaen_NZ
unitec.peerreviewedyesen_NZ
unitec.identifier.roms56495en_NZ


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