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    The Impact of Beta-blockade on Right Ventricular Function in Mitral Regurgitation

    Hongning, Yin; Stewart, Ralph A.; Whalley, Gillian

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    Date
    2014-04
    Citation:
    Hongning, Y., Stewart, R. A., and Whalley, G. A. (2014). The impact of beta-blockade on right ventricular function in mitral regurgitation. Heart, Lung and Circulation, 23, pp.378-380.
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/3017
    Abstract
    Background Although mitral regurgitation (MR) results in left ventricular (LV) volume overload, right ventricular (RV) function may also be impaired. We investigated the influence of short-term beta-blockade on RV function in patients with moderate-severe MR. Methods Twenty-six patients were randomised in a cross-over design to receive two weeks of beta-blockade or placebo. Echocardiography was performed at baseline and at the end of the treatment periods. Measure- ments included: RV ejection fraction (RVEF) tricuspid annular motion and Tei index. Results No differences in mean RVEF (64.0 ± 6.0 v 67.0 ± 8.0%, p = 0.3), tricuspid annular motion (13.5 ± 3.0 v 14.7 + 2.9 cm/s, p = 0.5), or median Tei index (0.61 (0.54, 0.88) v 0.59 (0.54, 0.74), p = 0.8) were observed between placebo and metoprolol, despite significantly longer cardiac time intervals. Tei index under both conditions was significantly reduced. Conclusions Short-term treatment with a beta-blocker did not influence RV function in these patients. Interestingly, the RV Tei index was high suggesting significant RV dysfunction despite normal RVEF.
    Keywords:
    mitral regurgitation, beta-blockers, Tei index, echocardiography, Doppler
    ANZSRC Field of Research:
    110201 Cardiology (incl. Cardiovascular Diseases)
    Copyright Holder:
    Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)
    Copyright Notice:
    © 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
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