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    Environmental bio-monitoring with high-throughput sequencing

    Wang, Jing; McLenachan, P.A.; Biggs, Patrick J.; Winder, Linton; Schoenfeld, Barbara I.K.; Narayan, Vinay V.; Phiri, Bernard J.; Lockhart, Peter

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    Wang et al 2013.pdf (338.3Kb)
    Date
    2013-05-15
    Citation:
    Wang, J., McLenachan, P.J., Biggs, P.J., Winder, L. H., Schoenfeld, B.I.K., Narayan, V.V., Phiri, B.J., and Lockhart, P.J. (2013). Environmental bio-monitoring with high-throughput sequencing. Briefings in Bioinformatics.
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/2644
    Abstract
    There is much interest in using high-throughput DNA sequencing methodology to monitor microorganisms, complex plant and animal communities. However, there are experimental and analytical issues to consider before applying a sequencing technology, which was originally developed for genome projects, to ecological projects. Many of these issues have been highlighted by recent microbial studies. Understanding how high-throughput sequencing is best implemented is important for the interpretation of recent results and the success of future applications. Addressing complex biological questions with metagenomics requires the interaction of researchers who bring different skill sets to problem solving. Educators can help by nurturing a collaborative interdisciplinary approach to genome science, which is essential for effective problem solving. Educators are in a position to help students, teachers, the public and policy makers interpret the new knowledge that metagenomics brings. To do this, they need to understand, not only the excitement of the science but also the pitfalls and shortcomings of methodology and research designs. We review these issues and some of the research directions that are helping to move the field forward.
    Keywords:
    metagenomics, environmental bio-monitoring, high-throughput sequencing
    ANZSRC Field of Research:
    0602 Ecology, 060407 Genome Structure and Regulation
    Copyright Holder:
    The Authors
    Copyright Notice:
    © The Author 2013. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
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