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    Known and missing left v entricular ejection fraction and survival in patients with heart failure : a MAGGIC meta-analysis report

    Poppe, K.K.; Squire, I.B.; Whalley, Gillian

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    Poppe_et_al-2013-European_Journal_of_Heart_Failure.pdf (143.4Kb)
    Date
    2013-06-26
    Citation:
    Poppe, K.K. et al. (2013) Known and missing left v entricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report. European Journal of Heart Failure (2013) 15, 1220–1227.
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/2591
    Abstract
    Aims Treatment of patients with heart failure (HF) relies on measurement of LVEF. However, the extent to which EF isrecorded varies markedly. We sought to characterize the patient group that is missing a measure of EF, and toexplore the association between missing EF and outcome.Methodsand resultsIndividual data on 30 445 patients from 28 observational studies in the Meta-Analysis Global Group in Chronic HeartFailure (MAGGIC) project were used to compare the prevalence of co-morbidities and outcome across three groupsof HF patients: those with missing EF (HF-mEF), reduced EF (HF-REF), and preserved EF (HF-PEF). A total of 29% hadHF-mEF, 52% HF-REF, and 19% HF-PEF. Compared with patients in whom EF was known, patients with HF-mEF wereolder, had a greater prevalence of COPD and previous stroke, and were smokers. Patients with HF-mEF were lesslikely to receive evidence-based treatment than those with HF-REF. Adjusted mortality in HF-mEF was similar to thatin HF-REF and greater than that in HF-PEF at 3 years [HF-REF, hazard ratio (HR) 1.03, 95% confidence interval (CI)0.95–1.12); HF-PEF, HR 0.78, 95% CI 0.71–0.86].Conclusion Missing EF is common. The short- and long-term outcome of patients with HF-mEF is poor and they exhibit different co-morbidity profiles and treatment patterns compared with patients with known EF. HF patients with missing EF represent ahigh risk group.
    Keywords:
    heart failure, outcomes, meta-analysis, ejection fraction, missing data
    ANZSRC Field of Research:
    110201 Cardiology (incl. Cardiovascular Diseases)
    Copyright Holder:
    John Wiley & Sons Ltd.
    Available Online at:
    http://onlinelibrary.wiley.com/doi/10.1093/eurjhf/hft101/epdf
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
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