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dc.contributor.authorSands, Gregory B.
dc.contributor.authorPope, Adèle J.
dc.contributor.authorLeGrice, Ian J.
dc.contributor.authorWhalley, Gillian
dc.contributor.authorDoughty, Robert N.
dc.contributor.authorSmaill, Bruce H.
dc.date.accessioned2014-12-02T23:00:51Z
dc.date.available2014-12-02T23:00:51Z
dc.date.issued2012-09-21
dc.identifier.issn1522-1539
dc.identifier.urihttps://hdl.handle.net/10652/2502
dc.description.abstractThe progression of hypertensive heart disease (HHD) to heart failure (HF) is associated with myocardial remodeling. Corresponding changes in three-dimensional organization of cardiac extracellular matrix have not been quantified or related fully to the development of HF. Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto controls were studied at 3, 12, 18, and 24 mo. Hemodynamic and morphological data, brain natriuretic peptide levels, and echocardiography demonstrate four distinct disease stages: systemic hypertension, diastolic dysfunction, early systolic failure, and decompensated HF. Passive left ventricular (LV) pressure-volume relationships were determined in vitro. Transmural specimens from the anterior LV free wall were imaged using extendedvolume confocal microscopy, and three-dimensional myocardial architecture was quantified. In SHRs, LV compliance was reduced at 12 mo and increased progressively thereafter. However, it was less than in controls for filling pressures 10 mmHg and not significantly different at 10 mmHg. Myocyte cross section was enlarged, with increased variability from 12 mo, while collagen fraction increased progressively. Perimysial collagen fraction remained unchanged with age, although endomysial collagen increased from 12 mo. Perimysial collagen between adjacent muscle layers fused at 12 mo and continued to thicken subsequently, while muscle layers became more dispersed and disordered. We conclude that LV dilatation, which accompanies decompensated HF in this model of HHD, is not due to LV “softening.” While perimysial (and endomysial) collagen networks are substantially remodeled, they are not dissolved, as has been proposed. We argue that progressive disruption of the laminar organization of LV myocardium may contribute to impaired systolic function in HHD.en_NZ
dc.language.isoenen_NZ
dc.publisherAmerican Physiological Societyen_NZ
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/23001837en_NZ
dc.subjecthypertensionen_NZ
dc.subjectcardiomyopathyen_NZ
dc.subjectconnective tissueen_NZ
dc.subjectperimysiumen_NZ
dc.subjectendomysiumen_NZ
dc.subjectmyocardiumen_NZ
dc.subjectlaminar architectureen_NZ
dc.titleProgression of myocardial remodeling and mechanical and dysfunction in the spontaneously hypertensive raten_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderAmerican Physiological Societyen_NZ
dc.identifier.doidoi: 10.1152/ajpheart.00748.2011en_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationLeGrice, I.J., Pope, A.J., Sands, G. B., Whalley, G., Doughty. R.N. and Smaill, B.H. (2012). Progression of myocardial remodeling and mechanical and dysfunction in the spontaneously hypertensive rat. American Journal of Physiology. Heart and Circulatory Physiology (Online). 303, H1353-H1365.en_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.publication.spageH1353en_NZ
unitec.publication.lpageH1365en_NZ
unitec.publication.volume303en_NZ
unitec.publication.titleAmerican Journal of Physiology. Heart and Circulatory Physiologyen_NZ
unitec.peerreviewedyesen_NZ
unitec.identifier.roms55000en_NZ


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