• Login
    View Item 
    •   Research Bank Home
    • Study Areas
    • Health Sciences
    • Health Sciences Journal Articles
    • View Item
    •   Research Bank Home
    • Study Areas
    • Health Sciences
    • Health Sciences Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Role of echocardiographic left ventricular mass and carotid intima-media thickness in the cardiovascular risk assessment of asymptomatic patients with type 2 diabetes mellitus

    Poppe, K.K.; Whalley, Gillian; Somaratne, Jithendra B.; Keelan, S.; Bagg, Warwick; Triggs, C. M.; Doughty, Robert N.

    Thumbnail
    Share
    View fulltext online
    poppe_int med j 2011.pdf (409.1Kb)
    Date
    2011
    Citation:
    Poppe, K. K., Whalley, G. A., Somaratne, J. B., Keelan, S., Bagg, W., Triggs, C. M., & Doughty, R. N. (2011). Role of echocardiographic left ventricular mass and carotid intima‐media thickness in the cardiovascular risk assessment of asymptomatic patients with type 2 diabetes mellitus. Internal Medicine Journal, 41(5), 391-398.
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/2129
    Abstract
    Background: Standard cardiovascular (CV) risk assessment may underestimate risk in people with type 2 diabetes mellitus (T2DM). Cardiac and vascular imaging to detect subclinical disease may augment risk prediction. This study investigated the association between CV risk, left ventricular hypertrophy (LVH) and carotid intima-media thickness (CIMT) in patients with T2DM free of CV symptoms. Methods: People with T2DM without known CV disease were recruited from general practice. The 5-year risk of CV events was calculated using an adjusted Framingham equation and the prevalence of LVH and abnormal CIMT across bands of CV risk assessed. In those at intermediate risk, the number needed to scan (NNS) to reclassify one person to high risk was calculated across the group and compared in those above and below 55 years. The association between LV mass and CIMT was also assessed. Results: Mean age 57 years (SD11), 51% female. Median 5-year CV risk 14.3% (interquartile range 10.3, 19.5), 51% had LVH (American Society of Echocardiography criteria) and 31% an abnormal CIMT (age and sex criteria). In the 52% at intermediate risk, 37% had LVH and 36% an abnormal CIMT. The NNS was 1.7 using both imaging techniques, 2.7 using cardiac imaging alone or 2.8 using vascular imaging alone. Almost twice as many people >55 years had an abnormal CIMT than those <55 years. Conclusions: Cardiac and vascular imaging to detect subclinical disease can be used to augment prediction of CV risk in people with T2DM at intermediate risk. The value of reclassifying risk is as yet unproven and requires outcome data from intervention studies.
    Keywords:
    risk assessment, ultrasonography, carotid arteries, left ventricular hypertrophy, type 2 diabetes mellitus.
    ANZSRC Field of Research:
    110201 Cardiology (incl. Cardiovascular Diseases)
    Copyright Holder:
    © 2011 The Authors Internal Medicine Journal © 2011 Royal Australasian College of Physicians
    Available Online at:
    http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291445-5994
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
    Metadata
    Show detailed record
    This item appears in
    • Health Sciences Journal Articles [49]

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142
     

     

    Usage

    Downloads, last 12 months
    96
     
     

    Usage Statistics

    For this itemFor the Research Bank

    Share

    About

    About Research BankResearch at UnitecContact us

    Help for authors  

    How to add researchOpen Access GuideVersions Toolkit

    Register for updates  

    LoginRegister

    Browse Research Bank  

    EverywhereAcademic study areasAuthorDateSubjectTitleType of researchSupervisorThis CollectionAuthorDateSubjectTitleType of researchSupervisor

    Library home
    Send Feedback
    Research publications
    Unitec
    Moodle
    © Unitec Institute of Technology, Private Bag 92025, Victoria Street West, Auckland 1142