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    Prognostic Implications of Left Ventricular Dilation in Patients With Nonischemic Heart Failure: Interactions With Restrictive Filling Pattern and Mitral Regurgitation

    Whalley, Gillian; Ghio, Stefano; Temporelli, Pier L.; Marsan, Nina A.; Poppe, K.K.; Giannuzz, Pantaleo; Dini, Frank L.; Rossi, Andrea; Doughty, Robert N.

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    ghio congestive heart failure 2012.pdf (110.0Kb)
    Date
    2012
    Citation:
    Ghio, S., Temporelli, P. L., Marsan, N. A., Poppe, K., Giannuzzi, P., Dini, F. L., ... & Whalley, G. (2012). Prognostic Implications of Left Ventricular Dilation in Patients With Nonischemic Heart Failure: Interactions With Restrictive Filling Pattern and Mitral Regurgitation. Congestive Heart Failure, 18(4), 198-204.
    Permanent link to Research Bank record:
    https://hdl.handle.net/10652/2119
    Abstract
    The aim of this study was to evaluate whether small left ventricular (LV) volumes increase the negative prognostic impact of a restrictive filling pattern (RFP) and that of mitral regurgitation (MR) in patients with nonischemic heart failure (HF). The Meta-analysis Research Group in Echocardiography (MeRGE) is a meta-analysis that collated individual patient data from several prospective echocardiography outcome studies. This analysis was restricted to 10 studies and 601 patients with nonischemic HF. The role of MR was tested in a subgroup of 252 patients. A total of 106 deaths occurred during a median follow-up of 32 months. At multivariate analysis, RFP (hazard ratio [HR], 4.16; 95% confidence interval [CI], 1.54–11.23; P=.005) and New York Heart Association class III or IV (HR, 2.15; 95% CI, 1.33– 3.47; P=.001) were the independent predictors of poor prognosis, and there was no statistically significant interaction between LV dilation and RFP. Moderate ⁄ severe MR was associated with poorer outcome in the group of patients with normal volumes, whereas it was not a significant predictor of mortality in patients with any degree of LV dilation. In patients with nonischemic HF, RFP is the most important indicator of poor prognosis, irrespective of the degree of LV dilation. Normal LV volumes increase the negative prognostic impact of moderate to severe MR.
    ANZSRC Field of Research:
    110201 Cardiology (incl. Cardiovascular Diseases)
    Copyright Holder:
    Wiley
    Rights:
    This digital work is protected by copyright. It may be consulted by you, provided you comply with the provisions of the Act and the following conditions of use: Any use you make of these documents or images must be for research or private study purposes only, and you may not make them available to any other person. You will recognise the author's and publishers rights and give due acknowledgement where appropriate.
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    • Natural Sciences Journal Articles [133]

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