Review : heart failure with preserved ejection fraction
Rigolli, Marzia; Whalley, Gillian
Citation:Rigolli, M., Whalley, G.A. (2013). Review : heart failure with preserved ejection fraction. Journal of Geriatric Cardiology 10: 369376. 1671-5411 doi: 10.3969/j.issn.1671-5411.2013.04.011
Permanent link to Research Bank record:http://hdl.handle.net/10652/3014
Progressive aging of the population and prolongation of life expectancy have led to the rising prevalence of heart failure (HF). Despite the improvements in medical therapy, the mortality rate of this condition has remained unacceptably high, becoming the primary cause of death in the elderly population. Almost half of patients with signs and symptoms of HF are found to have a nearly normal ejection fraction, which delineates a distinct clinical syndrome, known as HF with preserved ejection fraction (HF-PEF). While early research focused on the importance of diastolic dysfunction, more recent studies reported the pathophysiological complexity of the disease with multiple cardiovas- cular abnormalities contributing to its development and progression. HF-PEF is a challenging major health problem with yet no solution as there is no evidence-based treatment which improves clinical outcomes. This review summarizes the state of current knowledge on diagnosis, prognosis and treatment of HF-PEF, with particular insights on the pathological characteristics in the elderly population.
Keywords:diastole, echocardiography, mortality, preserved ejection fraction, heart failure
ANZSRC Field of Research:110201 Cardiology (incl. Cardiovascular Diseases)
Copyright Notice:2013 JGC All rights reserved; www.jgc301.com
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